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Global Pharmaceutical and Medical Research Conference (GPMRC) 2017
14-15 April - Sheraton Dubai Creek, UAE
3- Is Long-Term Use of Proton Pump Inhibitors Justified?
Amal Alakresh, and Eman Alobary
Introduction: Many patients are using proton pump inhibitors (PPI) for the treatment of acid-related diseases. The long-term treatment with PPI may be associated with several adverse effects and may affect the absorption of some medications.
Objective: The aim of this study is to assess the justification for long-term use of PPI in outpatient clinics in Prince Sultan Medical Military City (PSMMC) in Riyadh. It also included the assessment and detection of adverse effects during long-term PPI administration.
Methods: A retrospective cross-sectional study using medical records data at PSMMC for the evaluation of long-term use of PPI and to investigate any adverse effects associated with long-term administration of PPI.
Results: In this study, 700 patients were screened, out of which 81 patients were fit for our study criteria. 54% of the patients were females. The mean age was 57.3 years and the mean duration of PPI use was 4.8 years (2 to 14.2 years). 70.4% of the patients were using Esomeprazole and 26.6% were using Pantoprazole. The indications included gastro-esophageal reflux disease (GERD) in 48.2%, prevention of NSAIDs induced ulcer in 17.3%, no clear indication in 17.3%, gastritis in 6.1%, H. pylori in 2.5% and other indications in 8.6% (Barrett’s esophagus, treatment of NSAIDs induced ulcer, patients on corticosteroid or antithrombotic treatment). The adverse effects of PPI use included hypomagnesaemia in 25.7%, hypocalcemia in 7.9%, anemia in 41.3%, low iron level in 16%, osteoporosis in 9.9% and CAP in 14.8% with no Clostridium difficile infection found.
Conclusion: Many patients have been taking PPI for long durations with unjustified indications, subsequently exposing the patients for the development of unnecessary adverse effects.
4- Effect of Punica granatum Rinds Dried Powder on Wound Healing in Albino Rats of Wistar Strain
Nouf Alshammari, Fatima Nudrat, and Naira Nayeem
Introduction: A bed sore, also known as pressure ulcer is an area of unrelieved pressure over a defined area, usually over a bony prominence, which results in ischemia, cell death, and tissue necrosis. It is a common problem that develops as a complication in long term bedridden patients. In this research, a herbal medicine that is traditionally used in the Northern region of Saudi Arabia for the treatment of severe conditions of bed sores is studied for the management of open wounds in male Wister Albino rats weighing between 150 g to 200 g.
Objective: To develop a cost effective and safe herbal medicine for bed sores and to scientifically prove the status of traditional herbal medicine that is used in the Northern region of Saudi Arabia. Materials and Methods In this study, 12 male albino rats of Wistar strain were selected and divided into 3 groups, each composed of 4 rats. A circular wound of 20 mm2 size was produced on the dorsal thoracic region of each rat using excision wound model. Group 1 rats were treated with the test drug (dried powder of Punica granatum rind), Group 2 rats were treated with Fucidin ointment and Group 3 rats were treated with blank vaseline. Treatment application was made using the standard method on alternate days while having the wounds measured by graph paper method. The animals were monitored daily for their general health.
Results: The data was collected and statistically analyzed using student t-test considering p<0.05 as statistically significant, between Group 1 and Group 2 rats with p<0.05. The result is significant at p ≤ 0.01 between Group 1 and Group 3 and there is no statistically significant difference between Group 2 and Group 3 rats. The effect of Punica granatum rinds in Group 1 exhibited highly significant activity compared to Fucidin and Vaseline in Groups 2 and 3 respectively. Wound healing occurred on days 15, 17 and 21 days in groups 1, 2, 3 respectively.
Conclusion: In our study, significant results were seen in the management of wounds using Punica granatum rinds on rats. We suggest the conduction of further studies on a larger scale as our results might encourage industrial experts to manufacture a formulation which is cost effective and safe for bed sore management.
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